منابع مشابه
Sphingolipid imbalance can take out an eye
Sphingolipid imbalance can take out an eye Y onamine et al. report that the relative amounts of two sphingolipids control the breakdown of light-sensing proteins and determine whether eye cells survive. Sphingolipids aren’t just building blocks of membranes. Some of the molecules, such as sphingosine 1 phosphate (S1P) and dihydrosphingosine 1 phosphate (DHS1P), take part in signaling pathways t...
متن کاملSorting out Receptor Trafficking
in membrane or luminal/extracellular domains of these proteins, while somatodendritic signals, like basolateral signals, are found in cytoplasmic domains. However, Establishing and maintaining the proper spatial distribu-there are also contradictions to this " analogous mem-tion of integral membrane proteins is a functional neces-brane domain " hypothesis. Previous structure–function sity of al...
متن کاملMyelin Biogenesis: Sorting out Protein Trafficking
Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport and cytoskeletal dynamics. Recent studies indicate that soluble neuronal signals may control the surface expression of proteolipid protein, a process that involves reduced endocytosis and/or increased transport carrier recruitment from an intracellular pool.
متن کاملThe lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.
Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the lysosomes of I-cell disease (ICD) patients, a condition resulting from a mutation in the phosphotransferase that adds mannose 6-phosphate to hydrolases, have near normal levels of several lysosomal proteins, including the sphingolipid activator proteins (SAPs), GM2AP and pro...
متن کاملLabeled chemical biology tools for investigating sphingolipid metabolism, trafficking and interaction with lipids and proteins.
The unraveling of sphingolipid metabolism and function in the last 40 years relied on the extensive study of inherited human disease and specifically-tailored mouse models. However, only few of the achievements made so far would have been possible without chemical biology tools, such as fluorescent and/or radio-labeled and other artificial substrates, (mechanism-based) enzyme inhibitors, cross-...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 1992
ISSN: 0962-8924
DOI: 10.1016/0962-8924(92)90182-m